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Next-Gen Painkiller Blocks Pain Without the High

Neuroscience News - 20 May 2025 16:59
Next-Gen Painkiller Blocks Pain Without the High Summary: A new experimental drug, SBI-810, may deliver potent pain relief without the addictive and harmful side effects of opioids. Unlike opioids, SBI-810 precisely targets a single brain receptor pathway linked to pain reduction, avoiding the euphoric "high" and dangerous complications. In mice, the drug effectively relieved pain from surgery, fractures, and nerve injury, and even enhanced opioid effects at lower doses without causing tolerance. It also outperformed current medications like g...
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